A course of treatment lasts 5 days

Take 2 pink nirmatrelvir tablets and 1 white ritonavir tablet. Take these 3 tablets at the same time, twice a day (in the morning and again in the evening) for 5 days.

Each daily blister card shows your morning and evening dose, as follows:

Dose for patients with moderate kidney impairment:

If you have kidney problems, talk to your healthcare professional. You may need to take a lower dose.

Adults with moderate kidney impairment:
Take 1 pink nirmatrelvir tablet and 1 white ritonavir tablet. Take both tablets at the same time, twice a day (in the morning and again in the evening) for 5 days.

Each daily blister card shows your morning and evening dose, as follows:

How to take PAXLOVID

• PAXLOVID consists of 2 medicines co-packaged together:
  • nirmatrelvir (pink tablet)
  • ritonavir (white tablet)
• You must always take the nirmatrelvir tablet(s) at the same time as the ritonavir tablet.
• Always take PAXLOVID exactly as your healthcare professional has told you to.
• Check with your healthcare professional if you are not sure.
• You can take PAXLOVID with or without food.
• Swallow the tablets whole. Do not break, chew or crush the tablets.
• You must take PAXLOVID for 5 days in a row. Complete the entire 5-day treatment with PAXLOVID.
• Even if you feel better, do not stop taking PAXLOVID without talking to your healthcare professional.
• Talk to your doctor if you do not feel better or if you feel worse after 5 days.
• If you have kidney problems, talk to your healthcare professional. You may need to take a lower dose.
• If you think you, or a person you are caring for, have taken too much PAXLOVID, contact a healthcare professional, hospital emergency department, or regional poison control centre immediately, even if there are no symptoms.
• If you miss a dose of PAXLOVID within 8 hours of the time it is usually taken, take it as soon as you remember. If you miss a dose by more than 8 hours, skip the missed dose and take the next dose at your regular time. Do not take 2 doses of PAXLOVID at the same time.

How PAXLOVID is supplied

PAXLOVID is supplied in two different Dose Packs. The Dose Packs differ in the number of nirmatrelvir tablets they contain. Your healthcare professional will prescribe the Dose Pack that is right for you. Each Dose Pack contains the following:

What should I tell my healthcare provider before I take PAXLOVID?

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take PAXLOVID. Talk about any health conditions or problems you may have, including if you:

• Have or have had a kidney disease
• Have or have had a liver disease
• Have uncontrolled or undiagnosed HIV infection

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements, or alternative medicines.

Other warnings you should know about:
Liver Problems: Before you take PAXLOVID, tell your healthcare professional if you have any liver problems.
Pregnancy and Birth Control: Tell your healthcare professional if you are pregnant, think you might be pregnant, or are planning to become pregnant. You should not take PAXLOVID if you are pregnant unless your healthcare professional advises that you can.
Breastfeeding: Tell your healthcare professional if you are breastfeeding or plan to breastfeed. PAXLOVID can pass into your breastmilk. Your healthcare professional will tell you if you can breastfeed your baby while taking PAXLOVID.
Severe Allergic Reactions and Severe Skin Reactions: Before you take PAXLOVID, tell your healthcare professional if you are allergic to nirmatrelvir, ritonavir, or to any other ingredient in PAXLOVID.
Cholesterol-lowering Medicines: Before you take PAXLOVID, tell your healthcare professional if you are taking a cholesterol-lowering medicine such as lovastatin or simvastatin. PAXLOVID may increase the amount of these medicines in your body.

Do not take PAXLOVID if you are taking any of the medicines listed under the “Do not use PAXLOVID if” section. Taking PAXLOVID with these medicines may cause serious life-threatening side effects.

Do not use PAXLOVID if:

• You are allergic to nirmatrelvir, ritonavir, or to any of the other ingredients in PAXLOVID (see What are the ingredients in PAXLOVID?).
• You are taking any of the following medicines:
  • alfuzosin, used to treat signs and symptoms of an enlarged prostate gland
  • amiodarone, bepridil*, dronedarone, flecainide, propafenone, quinidine*, used to treat irregular heartbeats
  • apalutamide, used for prostate cancer
  • astemizole* or terfenadine*, used to relieve allergy symptoms
  • carbamazepine, phenobarbital, primidone, phenytoin, typically used to treat seizures (epilepsy)
  • cisapride*, used to relieve certain stomach problems
  • colchicine, when used in patients with kidney and/or liver problems, used to treat gout
  • eletriptan, ubrogepant, used to treat migraine
  • eplerenone, ivabradine, used to treat heart failure and high blood pressure
  • ergotamine*, dihydroergotamine (used to treat headaches), ergonovine, methylergonovine* (used after labour and delivery or abortion)
  • finerenone, used to treat adults with chronic kidney disease and type 2 diabetes
  • flibanserin, used to treat hypoactive sexual desire disorder in women
  • fusidic acid, used as an antibiotic
  • ovastatin, lomitapide, or simvastatin, used to lower cholesterol
  • lumacaftor/ivacaftor, used to treat cystic fibrosis
  • lurasidone, pimozide, used to treat mental health problems
  • naloxegol, used to treat constipation caused by narcotic pain medications
  • neratinib, used to treat breast cancer
  • ranolazine, used to treat chronic angina (chest pain)
  • rifampin (used to treat tuberculosis) together with saquinavir/ritonavir (anti-HIV medication)
  • rivaroxaban, used as an anticoagulant
  • salmeterol, used for asthma and chronic obstructive pulmonary disease
  • sildenafil, when used for the treatment of pulmonary arterial hypertension (PAH)
  • silodosin, used to treat signs and symptoms of an enlarged prostate gland
  • St. John’s Wort (Hypericum perforatum), an herbal product used to treat depression
  • tolvaptan, used to treat low sodium in the blood
  • triazolam and midazolam (oral* or injected), used to relieve anxiety and/or trouble sleeping
  • vardenafil, used to treat erectile dysfunction
  • venetoclax, used to treat chronic lymphocytic leukemia
  • voriconazole, used as an antifungal

The following may also interact with PAXLOVID:

• medicines used to treat erectile dysfunction, such as sildenafil and tadalafil
• medicines used to treat pulmonary arterial hypertension, such as bosentan, riociguat, or tadalafil
• medicines used to lower blood cholesterol, such as atorvastatin and rosuvastatin
• some medicines affecting the immune system, such as cyclosporin, everolimus, sirolimus, and tacrolimus
• some medicines used to treat seasonal allergies and ear and eye infections, such as budesonide, dexamethasone, fluticasone propionate, prednisone and triamcinolone
• medicines used to treat HIV and related infections, such as amprenavir, bictegravir, efavirenz, indinavir*, nelfinavir, saquinavir, didanosine*, rifabutin, tipranavir, delavirdine*, atazanavir, maraviroc, fosamprenavir, raltegravir, tenofovir, nevirapine, zidovudine, emtricitabine, and darunavir
• medicines used to treat depression, such as trazodone, desipramine, and bupropion
• certain heart medicines, such as calcium channel antagonists, including amlodipine, diltiazem, felodipine, nicardipine, nifedipine, and verapamil
• medicines used to treat men with symptoms of an enlarged prostate such as tamsulosin
• medicines used to correct heart rhythm, such as systemic digoxin and lidocaine, disopyramide and, mexiletine
• medicines used to treat heart or blood vessel problems such as aliskiren, and vorapaxar
• certain blood thinners such as apixaban, clopidogrel, dabigatran, ticagrelor, and warfarin
• antifungals, such as ketoconazole, isavuconazonium sulfate, and itraconazole*
• morphine-like medicines used to treat severe pain, such as methadone and meperidine
• certain antibiotics, such as rifabutin, erythromycin, and clarithromycin
• antibiotics used in the treatment of tuberculosis, such as rifampin
• bronchodilators used to treat asthma, such as theophylline
• medicines used to treat cancer, such as abemaciclib, ceritinib, dasatinib, encorafenib, ibrutinib, ivosidenib, nilotinib, vincristine, and vinblastine
• medicines used for low blood platelet count, such as fostamatinib
• some anticonvulsants, such as clonazepam, divalproex, lamotrigine, and ethosuximide
• some narcotic analgesics, such as fentanyl in all forms, hydrocodone, oxycodone, meperidine, tramadol, and propoxyphene
• quetiapine used to treat schizophrenia, bipolar disorder, and major depressive disorder
• medicines used to treat hepatitis C, such as simeprevir, glecaprevir/pibrentasvir, or ombitasvir/paritaprevir and ritonavir with or without dasabuvir*, elbasvir/grazoprevir, and sofosbuvir/velpatasvir/voxilaprevir
• some sedatives or medicines used to treat anxiety, such as buspirone, clorazepate, diazepam, flurazepam, and zolpidem
• stimulants, such as methamphetamine
• medicines used to treat pain associated with endometriosis, such as elagolix
• medicines used to treat depression, such as amitriptyline, clomipramine, fluoxetine, imipramine, maprotiline*, nefazodone*, nortriptyline, paroxetine, sertraline, and trimipramine, and venlafaxine
• medicines used to treat nausea and vomiting, such as dronabinol*
• medicines used to treat pneumonia, such as atovaquone
• medicines used as a sedative and medicines used to help you sleep (hypnotics), such as estazolam*
• medicines used to treat increased pressure in the eye, such as timolol
• medicines used to lower blood pressure, such as metoprolol
• medicines used to prevent organ rejection after a transplant, such as everolimus and sirolimus*
• medicines used to treat certain mental health and mood disorders (including schizophrenia and bipolar disorder), such as aripiprazole, brexpiprazole, cariprazine, clozapine, iloperidone*, lumateperone*, perphenazine, pimavanserin*, risperidone, suvorexant*, and thioridazine
• medicines used as hormonal contraceptives containing ethinyl estradiol (“the pill”)
• medicines used to treat cystic fibrosis such as ivacaftor, elexacaftor/tezacaftor/ivacaftor and tezacaftor/ivacaftor
• medicines used to control blood sugar levels, such as, saxagliptin
• medicines used to treat rheumatoid arthritis and psoriatic arthritis such as tofacitinib and upadacitinib
• medicines used to treat malaria such as quinine
• medicines used to treat symptoms of an overactive bladder such as darifenacin

* Product is not or no longer marketed in Canada

Pfizer is committed to ensuring that people have accurate
information about the drug PAXLOVID, including how it is
accessed and administered.